Science · Discoveries that changed the world

Can you edit a human being's DNA?

What if you could fix a letter in your DNA the way you fix a typo?

The CRISPR scissors4 min read5 partsQuiz of 8 questions
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For Emmanuelle Charpentier portrait, credit Bianca Fioretti of Hallbauer & Fioretti. For Jennifer Doudna portrait, credit User:Duncan.Hull and The Royal Society. · Emmanuelle Charpentier and Jennifer Doudna · CC BY-SA 4.0 · Wikimedia Commons
Part 1 of 5 · freeIntroduction

Hair, eyes, skin color, body shape: we all look different. These physical traits come down to inheritance: each gene is a segment of DNA received from our biological parents. Our surroundings matter too: what we eat, the people around us, what we believe. But we take our genes for granted. We might wish we were taller or thinner, but we live with them without a second thought.

What would you change if you could edit your DNA? The question is no longer theoretical. In 2012, an American biochemist, Jennifer Doudna, and a French microbiologist, Emmanuelle Charpentier, developed a way to program a protein that cuts DNA. From then on, they could remove an unwanted gene and so, in theory, edit the DNA of a human being.

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  1. 2CRISPR, scissors borrowed from bacteria
  2. 3The first cures: sickle cell disease and thalassemia
  3. 4Why we will not cure everything
  4. 5Designer babies: where do we draw the line?
Open-book quiz8 questions whose answers are in the text.
Glossary7 terms explained in a tap.
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